Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia.

@article{Santoso2016AntiendothelialA,
  title={Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia.},
  author={Sentot Santoso and Hevi Wihadmadyatami and Tamam Bakchoul and Silke Werth and Nadia Al-Fakhri and G. Bein and Volker Kiefel and Jieqing Zhu and Peter J. Newman and Behnaz Bayat and Ulrich Sachs},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2016},
  volume={36 8},
  pages={1517-24}
}
OBJECTIVE Fetal/neonatal alloimmune thrombocytopenia is a severe bleeding disorder, which can result in intracranial hemorrhage (ICH), leading to death or neurological sequelae. In whites, maternal anti-human platelet antigen-1a (HPA-1a) antibodies are responsible for the majority of cases. No predictive factors for ICH are available to guide prophylactic treatment during pregnancy. In this study, we investigated antibodies from mothers with ICH-positive fetal/neonatal alloimmune… CONTINUE READING
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