Antiemetic effects of sendide, a peptide tachykinin NK1 receptor antagonist, in the ferret.

@article{Minami1998AntiemeticEO,
  title={Antiemetic effects of sendide, a peptide tachykinin NK1 receptor antagonist, in the ferret.},
  author={Masaru Minami and Toru Endo and Kentaro Kikuchi and Emi Ihira and Masahiko Hirafuji and Naoya Hamaue and Yasutake Monma and Tsukasa Sakurada and Koichi Tan-no and Kensuke Kisara},
  journal={European journal of pharmacology},
  year={1998},
  volume={363 1},
  pages={49-55}
}
The antiemetic activity of sendide, a new peptide tachykinin NK1 receptor antagonist, against cisplatin-induced emesis was investigated using ferrets. The frequency of cisplatin (10 mg/kg, i.p.)-induced retching (104.6 +/- 14.3/6 h) and vomiting (19.0 +/- 3.0/6 h) was significantly reduced by pretreatment with sendide (3.0 mg/kg, s.c.) (14.0 +/- 8.1/6 h and 1.8 +/- 1.2/6 h, respectively). Intravenous bolus injection of substance P (1-10 microg/kg) or 5-hydroxytryptamine (5-HT) (10-50 microg/kg… CONTINUE READING