Antiemetic Activity of N‐Methyllevonantradol and Nabilone in Cisplatin‐Treated Cats

@article{McCarthy1981AntiemeticAO,
  title={Antiemetic Activity of N‐Methyllevonantradol and Nabilone in Cisplatin‐Treated Cats},
  author={Lawrence E. McCarthy and Herbert L. Borison},
  journal={The Journal of Clinical Pharmacology},
  year={1981},
  volume={21}
}
Abstract: The comprehensive emetic response to xenobiotics can be quantified by monitoring the physiological forces which effectuate vomiting. A unique sequence of thoracic pressure pulses, generated by the somatic muscles of ventilation, can be measured by means of a central venous catheter. This unambiguous emetic endpoint is used to record emetic latency, repetitions and duration of action, all on an established time base and dependent of stomach content. Deslanoside (160 μg/kg) produced… 
Antiemetic Effect of Intramuscular Levonantradol in Patients Receiving Anticancer Chemotherapy
TLDR
It is concluded that intramuscular levonantradol is an effective antiemetic at doses as low as 0.5 mg, and the most commonly reported side effects were somnolence and dry mouth.
Oral Levonantradol in the Treatment of Chemotherapy‐Induced Emesis: Preliminary Observations
TLDR
Although this study is preliminary, it appears that levonantradol is a relatively well‐tolerated oral antiemetic that deserves further evaluation.
Cisplatin-induced emesis in the cat: effect of granisetron and dexamethasone.
Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.
TLDR
The data suggest that lPBN-lesioned animals not only demonstrate pica after cisplatin treatment, but, in fact, show an exaggerated response that is greatly in excess of any treatment known to produce kaolin intake in rats.
EVALUATION OF SOME SELECTED MEDICINAL PLANTS AND THEIR COMBINATIONS IN CISPLATIN INDUCED VOMITING IN VOMIT MODEL(S); BEHAVIORAL NEUROCHEMICAL CORRELATES
TLDR
Vomiting was induced by highly emetogenic chemotherapeutic agent cisplatin in both models and the possible role of gastrointestinal (GIT) pro-kinetic properties on CIV in pigeon was examined, utilizing charcoal propulsion method.
A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
TLDR
A low dose of the non-intoxicating cannabinoid CBD may be an effective anti-emetic treatment and combined doses of OND and Δ9-THC that are ineffective alone suppresses cisplatin-induced emetic reactions in shrews.
Levonantradol: A Role for Central Prostanoid Mechanisms?
TLDR
A striking structural homology between PGE1 and levonantradol as elucidated by x‐ray and conformational studies is described, consistent with the generally recognized involvement of prostaglandins in pain and emesis and may have relevance to the site of levonantsradol's analgetic actions.
Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting
TLDR
Studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting are reviewed.
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