Antiemetic Activity of N‐Methyllevonantradol and Nabilone in Cisplatin‐Treated Cats

@article{McCarthy1981AntiemeticAO,
  title={Antiemetic Activity of N‐Methyllevonantradol and Nabilone in Cisplatin‐Treated Cats},
  author={L. McCarthy and H. Borison},
  journal={The Journal of Clinical Pharmacology},
  year={1981},
  volume={21}
}
Abstract: The comprehensive emetic response to xenobiotics can be quantified by monitoring the physiological forces which effectuate vomiting. A unique sequence of thoracic pressure pulses, generated by the somatic muscles of ventilation, can be measured by means of a central venous catheter. This unambiguous emetic endpoint is used to record emetic latency, repetitions and duration of action, all on an established time base and dependent of stomach content. Deslanoside (160 μg/kg) produced… Expand
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