Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers.

  title={Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers.},
  author={Sabah Oney and Shahid M. Nimjee and Juliana M Layzer and Nanette L S Que-Gewirth and David Ginsburg and Richard C. Becker and Gowthami Morey Arepally and Bruce A. Sullenger},
  volume={17 3},
Thrombus formation is initiated by platelets and leads to cardiovascular, cerebrovascular, and peripheral vascular disease, the leading causes of morbidity and mortality in the Western world. A number of antiplatelet drugs have improved clinical outcomes for thrombosis patients. However, their expanded use, especially in surgery, is limited by hemorrhage. Here, we describe an antiplatelet agent that can have its activity controlled by a matched antidote. We demonstrate that an RNA aptamer… CONTINUE READING