Antidotal Strategies in Phencyclidine Intoxication

@article{Giannini1985AntidotalSI,
  title={Antidotal Strategies in Phencyclidine Intoxication},
  author={A. James. Giannini and Matthew C. Giannini and William A. Price},
  journal={The International Journal of Psychiatry in Medicine},
  year={1985},
  volume={14},
  pages={315 - 321}
}
The authors present different antidotal strategies in treating phencyclidine (PCP) intoxication based upon specific symptomatic presentation. Evidence exists for dopaminergic, cholinergic and opiate-like activity of PCP in both laboratory and clinical studies. Reviewing these studies, clinical interventions are recommended according to various symptom clusters. 

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TLDR
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TLDR
Results of haloperidol treatment of PHP psychosis were similar to previously published reports with phencyclidine (PCP) psychosis.

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TLDR
The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role.

The Pharmacological Treatment of the Acute Intoxication and Detoxification of Alcohol and Drugs of Abuse and Addiction

TLDR
The biopsychiatric model explains how different drugs exert their effects and provides a rationale for specific pharmacological intervention in the drug-dependent patient.

Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.

TLDR
Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms and tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.

Psychedelic Drugs

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This chapter reviews preclinical and clinical research involving indolalkylamines, arylcyclohexamines, and substituted amphetamines, for which LSD, PCP, and MDMA are used as the prototypes, respectively.

Absence of Response to Histamine1Blockade

TLDR
Absence of Response to Histamine1 Blockade in Phencyclidine Toxicity is confirmed and this finding is consistent with previous reports of absence of response to histamine1 blockade in phencyclidine toxicity.

Drug testing: medical, legal, and ethical issues.

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TLDR
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