Antidotal Strategies in Phencyclidine Intoxication

  title={Antidotal Strategies in Phencyclidine Intoxication},
  author={A. James. Giannini and Matthew C. Giannini and William A. Price},
  journal={The International Journal of Psychiatry in Medicine},
  pages={315 - 321}
The authors present different antidotal strategies in treating phencyclidine (PCP) intoxication based upon specific symptomatic presentation. Evidence exists for dopaminergic, cholinergic and opiate-like activity of PCP in both laboratory and clinical studies. Reviewing these studies, clinical interventions are recommended according to various symptom clusters. 

Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.

While haloperidol was significantly more effective than ascorbic acid, the combination was significantlyMore effective than either used alone, suggesting this combination may have a specific antipsychotic role in the emergency treatment of PCP psychosis.

Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol.

Results of haloperidol treatment of PHP psychosis were similar to previously published reports with phencyclidine (PCP) psychosis.

Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.

The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role.

The Pharmacological Treatment of the Acute Intoxication and Detoxification of Alcohol and Drugs of Abuse and Addiction

The biopsychiatric model explains how different drugs exert their effects and provides a rationale for specific pharmacological intervention in the drug-dependent patient.

Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.

Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms and tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.

Psychedelic Drugs

This chapter reviews preclinical and clinical research involving indolalkylamines, arylcyclohexamines, and substituted amphetamines, for which LSD, PCP, and MDMA are used as the prototypes, respectively.

Absence of Response to Histamine1Blockade

Absence of Response to Histamine1 Blockade in Phencyclidine Toxicity is confirmed and this finding is consistent with previous reports of absence of response to histamine1 blockade in phencyclidine toxicity.

Drug testing: medical, legal, and ethical issues.



Physostigmine and haloperidol treatment of acute phencyclidine intoxication.

Twenty-four patients with phencyclidine intoxication were treated with either physostigmine (2 mg i.m.) or haloperidol (5 mg i.m.) based on the presence of delusions and/or hallucinations. Several

A case of phenylcyclohexylpyrrolidine (PHP) intoxication treated with physostigmine.

Treatment with physostigmine (IM) produced a rapid and sustained reversal of these symptoms following ingestion of phenylcyclohexylpyrrolidine.

Cholinolytic action of phencyclidine derivatives.

Psychotomimetic drugs as anticholinergic agents. II. Quantum-mechanical study of molecular interaction potentials of 1-cyclohexylpiperidine derivatives with the cholinergic receptor.

Experimental results referring to the psychotomimetic activity of the drugs and to their anti-acetylcholine properties were shown to correlate well with the structural requirements obtained from the interaction pharmacophore of acetyl choline.