Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus

@article{Eguchi1996AntidiureticAO,
  title={Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus},
  author={Takashi Eguchi and Yukio Takano and Tanenori Hatae and Ryo Saito and Yukiharu Nakayama and Yasufumi Shigeyoshi and Hitoshi Okamura and James E. Krause and Hiro-o Kamiya},
  journal={Brain Research},
  year={1996},
  volume={743},
  pages={49-55}
}
Studies were performed on the central antidiuretic actions via the tachykinin NK-3 receptor in the rat hypothalamic paraventricular nucleus (PVN). Microinjections of the selective tachykinin NK-3 receptor agonist senktide (2-200 pmol) into the PVN resulted in prolonged inhibition of urine output in water-loaded rats, its effect being dose-dependent. The antidiuretic action of senktide was blocked by pretreatment with the vasopressin V2 receptor antagonist OPC-31260 (1 mg/kg, i.v.), but not by… CONTINUE READING
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