Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action.

  title={Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action.},
  author={Vassilia Th{\'e}odorou and Maria Chovet and H{\'e}l{\`e}ne Eutam{\`e}ne and Helene Fargeau and M Dassaud and Mi hel Toulouse and Camille Bihoreau and François J. Roman and Lionel Bu{\'e}no},
  volume={51 4},
BACKGROUND AND AIMS Sigma ligands display antisecretory activity against various secretagogues, suggesting antidiarrhoeal properties. In this study, we evaluated: (i) the antidiarrhoeal effect of JO 2871, a high affinity sigma ligand, in three models of toxigenic diarrhoea in mice; and (ii) the site and mechanism of action of this compound. METHODS Faeces were collected after toxin or vehicle administration in male DBA2 or NMRI mice. Diarrhoea was determined by cumulative stool weight (mg… CONTINUE READING
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