Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.

  title={Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.},
  author={Paul Alozie Nwafor and F. K. Okwuasaba and Lucy Binda},
  journal={Journal of ethnopharmacology},
  volume={72 3},
The effect of methanolic extract of Asparagus pubescens root on experimentally-induced diarrhoea and ulceration was investigated in rats. The extract (500-1500 mg/kg) dose-dependently, reduced significantly the intestinal propulsive movement, castor oil-induced diarrhoea and intestinal fluid accumulation. Yohimbine an alpha(2)-adrenoceptor blocker attenuated the antidiarrhoeal effect of the extract. The extract also reduced the ulcer indices induced by indomethacin and ethanol in a dose-related… 
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The root extract of H. africana has antidiarrhoeal and antiulcer properties which justify its uses in ethnomedicine.
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The antidiarrhoeal activity of aqueous extract of Combretum sericeum roots was evaluated in rats. Studies were carried out on castor oil induced diarrhea, gastrointestinal motility and castor oil
Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.
  • J. Okokon, B. Antia, E. Umoh
  • Medicine
    African journal of traditional, complementary, and alternative medicines : AJTCAM
  • 2009
Lasianthera africana extract demonstrated a good antiulcer activity which supports the anti-ulcer effect of this plant in traditional medicine.
Antidiarrhoeal activity of Ziziphus mauritiana root extract in rodents
Preliminary phytochemical screening of the root extract of Ziziphus mauritiana revealed the presence of alkaloids, flavonoids, glycosides, saponins and volatile oil. Intraperitoneal LD50 of the
Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats.
The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents and it was suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiARRhoeal agent.
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The results of this work suggest that the leaf extract of Croton zambesicus possesses antiulcer activity, supporting the ethnomedical use of the plant.
The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats.
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Anti-diarrhoeal Activity of Ethanolic Extract of Celosia argentea ( Linn . )
Celosia argentea a medicinal herb belonging to the family Amaranthaceae has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. However the claims of ayurveda have to be
Antiulcerogenic activity of stem extract and fractions of Homalium Letestui
H. letestui extract demonstrated a good antiulcer activity which supports the use of this plant in the traditional medicine, and is comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models.


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An aqueous extract of Entandrophragma utile bark was shown to be efficacious in preventing experimental ethanol-induced ulcers in rats and the formation of a protective pellicle over the epithelial lining was observed, which may be due to the presence of tannins in the herbal medicine.
Contraceptive and non-estrogenic effects of methanolic extract of Asparagus pubescens root in experimental animals.
The methanolic extract of Asparagus pubescens Bak root was investigated for its contraceptive activity in mice, rats and rabbits and did not induce any uterotrophic effects or immature vaginal opening when compared to estrogen treated groups.
Protective dietary factors in experimental ulceration—study of some Nigerian cereals and tubers
Rats fed on a supplement of millet, Guinea-corn, rice or maize given in addition to laboratory stock diet showed a high degree of protection against experimental ulceration following indomethacin administration, indicating the geographical distribution of duodenal ulcer in Nigeria is discussed.
Effects of quercetin on the gastrointestinal tract in rats and mice
It is suggested that α2‐adrenergic receptors mediate the effect of quercetin on intestinal motility and secretion.
Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.
The gastric ulcers produced by indomethacin and oxyphenbutazone were significantly reduced by pretreatment with phenoxy-benzamine, phentolamine and by prior bilateral adrenalectomy and spinal cord transection while imipramine pre-treatment potentiated their incidence.
Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis
It is concluded that delay of castor oil‐induced diarrhoea in rats allows a detailed characterization of aspirin‐like compounds, and that inhibition of prostaglandin biosynthesis is insufficient to suppress the intestinal effects of the oil.
The protective effects of sulphasalazine against ethanol‐induced gastric damage in rats
This study elucidates the protective effects of sulphasalazine against ethanol‐induced gastric lesions and appears to be mediated, at least partly, through the preservation of gastric wall mucus by sulphapyridine.
Effects of Antiinflammatory Agents and Prostaglandins on Acid and Bicarbonate Secretions in the Amphibian-Isolated Gastric Mucosa
Abstract Effects of antiinflammatory agents and prostaglandins on H + and HCO − 3 secretions and electrical properties were investigated in the amphibian-isolated gastric mucosa. Gastric HCO − 3
Sulphasalazine and PhCL28A inhibit the formation of ethanol‐ and phenylbutazone‐induced rat gastric ulcers: lack of involvement of endogenous prostaglandins?
The results conclude that the anti gastric ulcer activity of SZP and PhCL28A is independent of prostaglandin inactivation and endogenous prostaglandsin formation is probably not involved.
Enteropooling assay: a test for diarrhea produced by prostaglandins.
The hypothesis that the diarrhea observed after administration of high doses of prostaglandins is due to accumulation of abundant fluid into the small intestine, and not intestinal hypermotility, is supported.