Antidiarrheal effects of a thermostable protein fraction obtained from the larvae of Musca domestica.

@article{Shen2019AntidiarrhealEO,
  title={Antidiarrheal effects of a thermostable protein fraction obtained from the larvae of Musca domestica.},
  author={Juan Shen and Jiali Chen and Depo Yang and Zhimin Zhao and C. Tang and Rongfei Zhang and Wenzhe Yang and Yi Niu},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2019},
  volume={115},
  pages={
          108813
        }
}
  • Juan Shen, Jiali Chen, +5 authors Yi Niu
  • Published 2019
  • Chemistry, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Our objective was to investigate whether a thermostable protein fraction (TPF) obtained from the larvae of Musca domestica, which contains cecropin family AMPs, is effective in treating senna leaf (Folium Sennae)-induced diarrhea in mice and its possible underlying mechanism. We did the experiments both in vitro and in vivo. Firstly, lipopolysaccharide (LPS) was used to induce inflammation in RAW 264.7 macrophages. The expression level of nitric oxide (NO) and tumor necrosis factor (TNF)-α was… Expand
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