Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes.

  title={Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes.},
  author={Bo Ahr{\'e}n and Jens Juul Holst and Suad Efend{\'i}c},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={85 3},
Cholecystokinin (CCK) is a gut hormone and a neuropeptide that has the capacity to stimulate insulin secretion. As insulin secretion is impaired in type 2 diabetes, we explored whether exogenous administration of this peptide exerts antidiabetogenic action. The C-terminal octapeptide of CCK (CCK-8) was therefore infused i.v. (24 pmol/kg x h) for 90 min in six healthy postmenopausal women and in six postmenopausal women with type 2 diabetes. At 15 min after start of infusion, a meal was served… CONTINUE READING