Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.

@article{Kallen1996AntidiabeticTI,
  title={Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.},
  author={Caleb B. Kallen and Mitchell A Lazar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 12},
  pages={5793-6}
}
Lack of leptin (ob) protein causes obesity in mice. The leptin gene product is important for normal regulation of appetite and metabolic rate and is produced exclusively by adipocytes. Leptin mRNA was induced during the adipose conversion of 3T3-L1 cells, which are useful for studying adipocyte differentiation and function under controlled conditions. We studied leptin regulation by antidiabetic thiazolidinedione compounds, which are ligands for the adipocyte-specific nuclear receptor… CONTINUE READING