Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum.

@article{Zhang2007AntidiabeticPO,
  title={Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum.},
  author={Junzeng Zhang and Christa Tiller and Jingkai Shen and C. Wang and Gabrielle S Girouard and Dorothy A. Dennis and Colin James Barrow and Mingsan Miao and H. Stephen Ewart},
  journal={Canadian journal of physiology and pharmacology},
  year={2007},
  volume={85 11},
  pages={1116-23}
}
We screened seaweed species from Atlantic Canada for antidiabetic activity by testing extracts for alpha-glucosidase inhibitory effect and glucose uptake stimulatory activity. An aqueous ethanolic extract of Ascophyllum nodosum was found to be active in both assays, inhibiting rat intestinal alpha-glucosidase (IC50 = 77 microg/mL) and stimulating basal glucose uptake into 3T3-L1 adipocytes during a 20-minute incubation by about 3-fold (at 400 microg/mL extract). Bioassay-guided fractionation of… CONTINUE READING

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