Antidiabetic effect of an active fraction extracted from dragon's blood (Dracaena Cochinchinensis).

Abstract

The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.

DOI: 10.1080/14756360801936399

Cite this paper

@article{Gu2009AntidiabeticEO, title={Antidiabetic effect of an active fraction extracted from dragon's blood (Dracaena Cochinchinensis).}, author={Hui-Juan Gu and Jing-Ci Lv and Ke-Lan Yong and Xu Chen and Pei-Pei Liu and Xia-Bing Zhang}, journal={Journal of enzyme inhibition and medicinal chemistry}, year={2009}, volume={24 1}, pages={136-9} }