Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase

@article{Jaiswal2012AntidiabeticEO,
  title={Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase},
  author={N. Jaiswal and V. Bhatia and S. Srivastava and A. Srivastava and A. Tamrakar},
  journal={Natural Product Research},
  year={2012},
  volume={26},
  pages={2363 - 2367}
}
The antidiabetic effect of the ethanolic extract of Eclipta alba (EEA) on hyperglycaemia and diabetic nephropathy was investigated in streptozotocin-induced diabetic rats. Single-dose treatment of EEA to streptozotocin-induced diabetic rats lowered the blood glucose level by 17.6% (p < 0.05) at 250 mg kg−1 dose after 5 h post oral administration. Treatment of animals after 10 weeks of STZ-treatment with EEA (250 mg kg−1) for 21 days significantly reduced the elevated levels of blood glucose… Expand
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References

SHOWING 1-10 OF 17 REFERENCES
Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats.
TLDR
Oral administration of E. alba at dose of 2 g/kg body weight exhibited better sugar reduction than 4 g/ kg body weight, and clearly shows that the oral administration of the plant possess potent antihyperglycemic activity. Expand
ANTIDIABETIC AND ANTIHYPERGLYCAEMIC EFFECTS OF NEEM SEEDS KERNEL POWDER ON ALLOXAN DIABETIC RABBITS
Objective: To study the effects of neem kernel powder(NP) and glibenclamide. alone or in combination, on alloxan diabetic rats. Methods: The diabetic rabbits were given with NP alone or inExpand
Pharmacology of alpha-glucosidase inhibition.
  • H. Bischoff
  • Medicine
  • European journal of clinical investigation
  • 1994
TLDR
The treatment of diabetic animals with acarbose does not only improve the metabolic state but has also the potential to delay, or possibly prevent, the development of diabetic complications. Expand
In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves.
TLDR
Fraction EaII (10-80 mg/kg, p.o.) containing coumestan wedelolactsone and desmethylwedelolactone as major components with apigenin, luteolin, 4-hydroxybenzoic acid and protocateuic acid as minor constituents exhibited maximum hepatoprotective activity and is the active fraction for hepatoprotsective activity of Eclipta alba leave. Expand
Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.
TLDR
Results showed that pongamol and karangin isolated from the fruits of Pongamia pinnata possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity. Expand
A thirty year journey in the polyol pathway.
TLDR
The prevention of sugar cataract formation by aldose reductase inhibitors dramatically demonstrates the role of this enzyme in sugar-induced cataracts and suggests that AR may play a role in the development of other diabetic complications. Expand
A superfamily of NADPH-dependent reductases in eukaryotes and prokaryotes.
TLDR
The complete protein sequence of rat lens AR is determined using cDNA analysis and primer extension of mRNA and sequence alignments reveal that 18% of the amino acids are completely conserved in all members of the NADPH-dependent reductases superfamily, many of them in clusters, suggesting that they mark important structural features such as the nucleotide binding site and substrate binding site. Expand
Natural products for type II diabetes treatment.
TLDR
Looking at existing and new methods of mass level production of digestive inhibitors and latest efforts to effectively discover new potential drugs is the subject of this book chapter. Expand
Medicinal plants of India with anti-diabetic potential.
TLDR
45 plants and their products that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity are reviewed. Expand
Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications.
TLDR
It is shown that intensive insulin treatment effectively delays the onset and slows the progression of longterm diabetic complications in patients with insulin-dependent diabetes mellitus (IDDM)b. Expand
...
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