Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway.
@article{Lu2018AntidiabeticCE, title={Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway.}, author={Qian Lu and Meng Hao and Wenya Wu and N. Zhang and Adelusi Temitope Isaac and Jiale Yin and X. Zhu and L. Du and Xiaoxing Yin}, journal={Acta biochimica Polonica}, year={2018}, volume={65 1}, pages={ 35-41 } }
One of the earliest critical secondary complications of diabetes is the opacification of the eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate the effect of Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced diabetic cataract (DC) rats. Ten weeks after administration of GbE, rutin and quercetin, the opacity of diabetic rats' lenses was graded under a slit lamp. Then, the levels of malondialdehyde… CONTINUE READING
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References
SHOWING 1-10 OF 47 REFERENCES
Preventative Effects of Ginkgo biloba Extract (EGb761) on High Glucose‐Cultured Opacity of Rat Lens
- Chemistry, Medicine
- Phytotherapy research : PTR
- 2014
- 20
Ginkgo biloba extract prevents against apoptosis induced by high glucose in human lens epithelial cells
- Biology, Medicine
- Acta Pharmacologica Sinica
- 2008
- 18
- PDF
Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats
- Medicine
- Molecular vision
- 2012
- 46
- PDF
Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats
- Medicine
- Acta Pharmacologica Sinica
- 2007
- 42
- PDF
Lutein prevents cataract development and progression in diabetic rats
- Medicine
- Graefe's Archive for Clinical and Experimental Ophthalmology
- 2008
- 65
Inhibition of advanced glycation end-product formation on eye lens protein by rutin
- Chemistry, Medicine
- British Journal of Nutrition
- 2011
- 49
- PDF
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract
- Medicine
- Interdisciplinary toxicology
- 2011
- 77
- PDF
Preventive effects of rutin on the development of experimental diabetic nephropathy in rats.
- Chemistry, Medicine
- Life sciences
- 2012
- 56
Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy.
- Medicine
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2015
- 48
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.
- Biology, Medicine
- International journal of molecular medicine
- 2008
- 81
- PDF