Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway.

@article{Lu2018AntidiabeticCE,
  title={Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway.},
  author={Qian Lu and Meng Hao and Wenya Wu and Nan Zhang and Adelusi Temitope Isaac and Jiale Yin and Xia Zhu and Lei Du and Xiaoxin Yin},
  journal={Acta biochimica Polonica},
  year={2018},
  volume={65 1},
  pages={
          35-41
        }
}
One of the earliest critical secondary complications of diabetes is the opacification of the eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate the effect of Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced diabetic cataract (DC) rats. Ten weeks after administration of GbE, rutin and quercetin, the opacity of diabetic rats' lenses was graded under a slit lamp. Then, the levels of malondialdehyde… Expand
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Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats
TLDR
It can be concluded that chrysin reveals antioxidative activity in the lenses but shows no antihyperglycemic or antiglycation properties. Expand
Effects of Ginkgo biloba on Diseases Related to Oxidative Stress.
TLDR
Ginkgo biloba can be a low-cost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities. Expand
Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway.
TLDR
The results revealed that quercetin inhibited MC proliferation in high glucose-treated mouse glomerular MCs and in DN via reactivation of the Hippo pathway. Expand
Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice
TLDR
Quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD, and mechanism studies showed that farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathways was involved in quercet in regulation of lipid metabolism in T2 DM‐inducedNAFLD. Expand
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling
TLDR
WJ-39 and its mechanism of amelioration of renal lesions in DN rats by reducing renal inflammation, oxidative stress, and fibrosis injury could be an effective strategy for the treatment of DN. Expand
Quercetin protects islet β-cells from oxidation-induced apoptosis via Sirt3 in T2DM
TLDR
Quercetin protected islet β-cells from oxidation-induced apoptosis via Sirt3 in T2DM, which would be beneficial to develop new strategies for preventing β-cell failure in T1DM. Expand
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications.
TLDR
The article overviews the aldose reductase as the causative agent and a potential target for the treatment of diabetic complications and several inhibitors, like derivatives of carboxylic acid, spirohydantoin, phenolic derivatives, etc. could prevent diabetic complications. Expand
Investigation of expression and effects of TGF-β1 and MMP-9 in lens epithelial cells of diabetic cataract rats
TLDR
The increased expression of MMP-9 and TGF-β1 may play an important role in the occurrence and development of diabetic cataract. Expand
Repression of Polyol Pathway Activity by Hemidesmus indicus var. pubescens R.Br. Linn Root Extract, an Aldose Reductase Inhibitor: An In Silico and Ex Vivo Study
Abstract Development of diabetic cataract is mainly associated with the accumulation of sorbitol via the polyol pathway through the action of Aldose reductase (AR). Hence, AR inhibitors are… Expand
Polyphenol-enriched fraction of Vaccinium uliginosum L. protects selenite-induced cataract formation in the lens of Sprague-Dawley rat pups
TLDR
FH showed a preventive effect against cataract formation by inhibiting m-calpain-mediated proteolysis and oxidative stress in the lens and suggest that FH could be a potential anticataract agent in age-related cataracts. Expand
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