• Corpus ID: 52251729

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Carpolobia lutea

@inproceedings{Akpan2012AntidiabeticAH,
  title={Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Carpolobia lutea},
  author={M M Akpan and Jude Efiom Okokon and Enomfon Jonah Akpan},
  year={2012}
}
Evaluation of antidiabetic and hypolipidemic activities of ethanolic leaf extract of Carpolobia lutea (245,490 and 735 mg/kg b.w.p.o) were carried out in alloxaninduced diabetic albino rats after a single dose (acute study) and after prolonged treatment(chronic study). The activity of the extract was compared with that of referenced drug,glibenclamide (10 mg/kg bw.p.o).The blood glucose level(BGL) was measured by using a glucometer and the various lipids level were estimated using Randox… 

Tables from this paper

Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis.

TLDR
It appears that the beneficial effect of methanol extract of C. lutea leaf observed in this study is dose dependent and is related to its antioxidant and anti-inflammatory activity.

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium-challenged rats

TLDR
It is suggested that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats, probably due to the extract’s potential in the management of testicular dysfunction and fecundity in animals.

Proximate and Phytochemical Compositions of Leaf and Root of (Cattle Stick) Carpolobia lutea G. Don

Carpolobia lutea is a medicinal plant commonly utilized in Nigeria to boost libido. The ethnomedicinal importance of any plant lies in some secondary metabolites. Hence, the present study was carried

The aphrodisiac herb Carpolobia: A biopharmacological and phytochemical review

TLDR
An overview of the morphology, taxonomy, ethnomedicinal claims, geographical distribution, and structurally elucidated compounds that are secondary metabolites isolated and characterized from Carpolobia species is established.

References

SHOWING 1-10 OF 35 REFERENCES

Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes.

Gastroprotective effects of leaf extracts of Carpolobia lutea (polygalaceae) G. Don. in rats

TLDR
The ethyl acetate extract consistently and effectively reduced the ulcer index significantly (p<0.001) than the ethanol, chloroform and nhexane extracts of C. lutea in all the experimentally induced ulcer models studied.

Antidiarrheal mechanism of Carpolobia lutea leaf fractions in rats

TLDR
The leaf fractions of Carpolobia lutea contain two types of antidiarrheal agents, one mediating its effect through α1-presynaptic adrenoceptor while the other does not, and polyphenols isolated may in part lend credence for observed antidiARRheal activity.

Analgesic activities of ethanolic extract of the root of Carpolobia lutea

TLDR
The data obtained shows that C. lutea posseses analgesic activity that is peripherally mediated, and oral administration of the extract up to 2500 mg/kg did not produce any toxic effects in the acute toxicity studies in mice.

Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice.

TLDR
It is concluded that aqueous extract perfusion of SP inhibits endogenous glucose production in mice, which is at least one mechanism explaining the observed hypoglycemic activity of this plant in diabetic animals.

Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models

TLDR
Its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms are confirmed, and its cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities.

Contraceptive, estrogenic and anti-estrogenic potentials of methanolic root extract of Carpolobia lutea in rodents.

TLDR
In ovariectomized immature young rats, the extract showed estrogenic effect in low doses while in high doses, it showed anti-estrogenic effect, which agrees with the traditional use of Carpolobia lutea in the control of fertility.

In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria.