• Corpus ID: 25856294

Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties.

@article{Sabu2004AntidiabeticAO,
  title={Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties.},
  author={Mandumpal Chacko Sabu and Ramadasan Kuttan},
  journal={Indian journal of physiology and pharmacology},
  year={2004},
  volume={48 1},
  pages={
          81-8
        }
}
Oxidative stress induced by alloxan has been shown to damage pancreatic beta-cell and produce hyperglycemia in rats. Aegle marmelos leaf extract is being used in Ayurveda as a medicine for diabetes. The present study examined the action of Aegle marmelos against experimental diabetes as well as the antioxidant potential of the drug. A methanolic extract of Aegle marmelos was found to reduce blood sugar in alloxan diabetic rats. Reduction in blood sugar could be seen from 6th day after… 

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Treatment with extracts of Eugenia jambolana seed and Aegle marmelos leaf prevents hyperglycemia and hyperlipidemia in alloxan induced diabetic rats.

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References

SHOWING 1-10 OF 20 REFERENCES

Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall. extract in streptozotocin-induced diabetic rats.

TLDR
Results suggest that S. oblonga root bark extract possesses anti-diabetic and anti-oxidative activity in streptozotocin-di diabetic rats.

Role of Oxidative Stress in Development of Complications in Diabetes

TLDR
Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.

Poor Glycaemic Control is Associated with Reduced Serum Free Radical Scavenging (Antioxidant) Activity in Non-Insulin-Dependent Diabetes Mellitus

TLDR
Results indicate that poor diabetic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus, and by implication improved glycaemic control may preserve serum antioxidant status in diabetes.

A simplified assay method of superoxide dismutase activity for clinical use.

A simple and inexpensive assay method of superoxide dismutase (SOD) activity of various biological materials has been developed. SOD activity can easily be measured by reading the medium's intense

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

TLDR
The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.

Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.

  • K. Satoh
  • Medicine, Chemistry
    Clinica chimica acta; international journal of clinical chemistry
  • 1978
TLDR
The average values determined by the new method increased slightly with age in healthy subjects, and in patients with sequelae of cerebrovascular disorders, serum lipid peroxide values were higher than in healthy controls.

Microsomal lipid peroxidation.

Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction*

TLDR
The insulin resistance of glucose transport in 3T3-L1 adipocytes exposed to TNF-α for 72-96 h results from a reduced amount in requisite proteins involved in insulin action, consistent with earlier studies indicating that T NF-α reduces the transcriptional activity of the GLUT4 gene in murine adipocytes, and reduced mRNA transcription of a number of relevant genes.