Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes.

  title={Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes.},
  author={Emmanuel Ohifueme Alegbe and Kerem Teralı and Kolawole Ayodapo Olofinsan and Serdar Surgun and Chukwuma C. Ogbaga and Taofeek Olakunle Ajiboye},
  journal={Journal of food biochemistry},
  volume={43 7},
We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α-amylase and α-glucosidase with IC50 of 411.73 and 433.93 μg/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited α-amylase with IC50 of 27.03 and 20.12 μg… 
Background: Hyphaene thebaica L. Mart. (Doum-palm), rich in total phenolics content, is known for its medicinal value in the treatment of several health conditions, such as hypertension, and diabetes
Phytochemical Constituents and Antibacterial Activities of Hibiscus sabdariffa L. Calyces (Zobo Flower) Extracts on Escherichia coli and Staphylococcus aureus
Introduction: Hibiscus sabdariffa plant has been used in many ways both for industrial purposes and medicinal uses. It has been discovered to have antimicrobial properties. Aim and objective: The
Methodologies in the Analysis of Phenolic Compounds in Roselle (Hibiscus sabdariffa L.): Composition, Biological Activity, and Beneficial Effects on Human Health
The applications of the analytical methods highlighted indicated that phenolic acids, flavonoids, and their derivatives have been identified and quantified in roselle with a range of biological activities and beneficial effects on human health.
Phenolics-Linked Antioxidant and Anti-hyperglycemic Properties of Edible Roselle (Hibiscus sabdariffa Linn.) Calyces Targeting Type 2 Diabetes Nutraceutical Benefits in vitro
Phenolics- enriched plant food sources are excellent dietary and therapeutic targets to combat the increasing prevalence of diet and lifestyle-influenced non-communicable chronic diseases (NCDs),
The Invasive Species Reynoutria japonica Houtt. as a Promising Natural Agent for Cardiovascular and Digestive System Illness
Graphical Abstract Polygoni Cuspidati Rhizoma et Radix, the dry roots and stems of Reynoutria japonica Houtt (called Huzhang, HZ in Chinese), is a traditional and popular chinese medicinal herb for
Immunomodulatory and Mechanistic Considerations of Hibiscus sabdariffa (HS) in Dysfunctional Immune Responses: A Systematic Review
HS may be promising in the management of disorders involving hyperactive immune system or chronic inflammation, and some of the results had high statistical heterogeneity.
The Ameliorative Role of Hibiscetin against High-Fat Diets and Streptozotocin-Induced Diabetes in Rodents via Inhibiting Tumor Necrosis Factor-α, Interleukin-1β, and Malondialdehyde Level
It was determined that hibiscetin may be beneficial in terms of reducing diabetes problems due to its effects on both oxidative stress and inflammation and that more research for this design should be conducted.


Bioactivity-guided isolation of antidiabetic principles from the methanolic leaf extract ofBryophyllum pinnatum
The antidiabetic principles from methanolic leaf extract of Bryophyllum pinnatum were isolated. The leaf extract was fractionated on silica gel using column chromatography and identified using
Aqueous extracts of Roselle (Hibiscus sabdariffa Linn.) varieties inhibit α-amylase and α-glucosidase activities in vitro.
Investigation of the inhibitory effect of aqueous extracts of two varieties of Hibiscus sabdariffa (Roselle) calyces on carbohydrate hydrolyzing enzymes and antioxidant properties revealed that the red variety possessed higher antioxidant capacity as exemplified by the (•)OH scavenging abilities, Fe(2+) chelating ability, and inhibition of Fe( 2+)-induced pancreatic lipid peroxidation in vitro.
Isolation of α-Amylase Inhibitors from Kadsura longipedunculata Using a High-Speed Counter-Current Chromatography Target Guided by Centrifugal Ultrafiltration with LC-MS
Results proved that the hyphenated technique using CU-LC-MS and HSCCC was a rapid, competent, and reproductive method to screen and separate potential active compounds, like enzyme inhibitors from the extract of herbal medicines.
Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract
Hibiscus sabdariffa anthocyanin extract can act as a prophylactic by intervening as a free radical scavenger both in vitro and in vivo as well as inducing the phase II drug detoxification enzymes.