Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes.

@article{Alegbe2019AntidiabeticAI,
  title={Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes.},
  author={Emmanuel Ohifueme Alegbe and Kerem Teralı and Kolawole Ayodapo Olofinsan and Serdar Surgun and Chukwuma C. Ogbaga and Taofeek Olakunle Ajiboye},
  journal={Journal of food biochemistry},
  year={2019},
  volume={43 7},
  pages={
          e12927
        }
}
We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α-amylase and α-glucosidase with IC50 of 411.73 and 433.93 μg/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited α-amylase with IC50 of 27.03 and 20.12 μg… 
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