Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

@article{Cao2003AntidiabeticAO,
  title={Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.},
  author={Guoqing Cao and Yu Liang and Carol L. Broderick and Brian A Oldham and Thomas P. Beyer and Robert J. Schmidt and Youyan Zhang and Keith R. Stayrook and Chen S. Suen and Keith A Otto and Anne Reifel Miller and Jiannong Dai and Patricia S Foxworthy and Hong Gao and Timothy P. Ryan and Xian-cheng Jiang and Thomas P Burris and Patrick I. Eacho and Garret J Etgen},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 2},
  pages={1131-6}
}
The oxysterol receptors LXR (liver X receptor)-alpha and LXRbeta are nuclear receptors that play a key role in regulation of cholesterol and fatty acid metabolism. We found that LXRs also play a significant role in glucose metabolism. Treatment of diabetic rodents with the LXR agonist, T0901317, resulted in dramatic reduction of plasma glucose. In insulin-resistant Zucker (fa/fa) rats, T0901317 significantly improved insulin sensitivity. Activation of LXR did not induce robust adipogenesis but… CONTINUE READING