Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling.

@article{Mohammed2013AntidiabeticDM,
  title={Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling.},
  author={Altaf Mohammed and Naveena B. Janakiram and Misty Brewer and Rebekah L. Ritchie and Anuj Marya and Stan A. Lightfoot and Vernon E. Steele and Chinthalapally V Rao},
  journal={Translational oncology},
  year={2013},
  volume={6 6},
  pages={
          649-59
        }
}
Epidemiologic studies have shown that diabetes mellitus is associated positively with increased risk of pancreatic ductal adenocarcinoma (PDAC), and recent meta-analysis studies showed that metformin, reduces the risk of pancreatic cancer (PC). We tested the effects of metformin on pancreatic intraepithelial neoplasia (PanIN) and their progression to PDAC in p48Cre/+.LSL-KrasG12D/+ transgenic mice. Mice fed control diet showed 80% and 62% incidence of PDAC in males and females, respectively… CONTINUE READING

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