Antidiabetic Activity of Alcoholic Extract of Neem (Azadirachta Indica) Root Bark

  title={Antidiabetic Activity of Alcoholic Extract of Neem (Azadirachta Indica) Root Bark},
  author={Prabhakar R. Patil and Sudha Patil and Abhay B Mane and Sushilkumar Verma},
  journal={National Journal of Physiology, Pharmacy and Pharmacology},
Background: Most of the parts of neem tree were studied in details by many researchers but neem root bark was not screened for antidiabetic effect. To evaluate antidiabetic effect of neem root bark this study was conducted. Aims & Objective: The present study was undertaken to evaluate the 70% alcoholic neem root bark extract (NRE) in diabetes. Materials and Methods: Basal blood sugar levels were estimated in overnight fasted wistar albino rats of either sex. To evaluate antihyperglycemic… Expand
Hypoglycaemic effects of dichloromethane: methanolic leaf and stem bark extracts of Pappea capensis in male Albino rats
There was evidence of recovery from alloxan-induced damage after administration of leaf and stem bark extracts of P. capensis and this followed a dose-related pattern, which may be attributed to the presence of phytochemicals such as glycosides, alkaloids, terpenoids, phenolics and flavonoids that are associated with hypoglycaemic activity. Expand
Anti-Diabetic Activity of Ethanolic Extract of Nerium Oleander Flowers In Alloxan Induced Diabetic Rats
Results suggest that Nerium oleander has a beneficial effect on diabetes. Expand
Hematological and histological effect of fractionated neem leaf extract in healthy Wistar rats
Prolonged administration of neem affected the histology of some organs of the rats more than the hematological parameters, and the effect of IRACARP® a fractionated neem leaf extract on the heMatological parameters and Histology of Wister rat tissues was investigated. Expand
Antidiabetic activities of ethyl acetate and aqueous extracts of pappea capensis, senna spectabilis, maytenus obscura, ocimum americanum and launaea cornuta
Pappea capensis, Senna spectabilis, Maytenus obscura, Launaea cornuta and Ocimum americanum have been used traditionally in the management of several diseases including diabetes mellitus but theirExpand
Antimicrobial activity of Azadirachta Indica (neem) leaves and stem bark aqueous extracts
Background: Azadirachta indica is a multipurpose tree called as Neem which is used in Ayurvedic medicine for skin infections and household pesticide.  Methods: Aqueous extraction of plant materialExpand
Therapeutics role of neem and its bioactive constituents in disease prevention and treatment
Azadirachta indica, commonly known as Neem, it is a member of the Meliaceae family. It has gained research interest worldwide prominence in recent years due to its wide range of medicinal propertiesExpand
Pharmacological and non pharmacological activity of Azadirachta indica (Neem) - a review.
The active component and pharmacological and non pharmacological uses of Neem are shown. Expand
The protective effect of Azadirachta indica (neem) against metabolic syndrome: A review
It has been shown that neem can control hyperglycemia and hypertension through over-expression of transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) and anti-oxidant effects andAnti-oxids play an important role in protective mechanisms of neem against metabolic syndrome and its complications. Expand
Traditional, Pharmacological and Patenting Potential of Neem (Azadirachta indica): A Review
This review is going to explore comprehensively; traditional, pharmacological potential along with patenting, environmental & industrial significant of various parts of neem tree with safety concerns. Expand
An overview of Neem (Azadirachta indica) and its potential impact on health
The health benefits found in diverse compounds and extracts derived from Neem are state, highlighting the mechanisms and pathways in which Neem compounds produce their effects, while warning that the improper and unstandardized conditions to produce extracts can lead to health issues. Expand


Hypoglycemic activity of Ficus hispida (bark) in normal and diabetic albino rats
Increased glycogenesis and enhanced peripheral uptake of glucose are the probable mechanisms involved in its hypoglycemic activity. Expand
The data suggests that A. indica could be of benefit in diabetes mellitus in controlling the blood sugar or may also be helpful in preventing or delaying the onset of the disease. Expand
Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats.
Present studies besides confirming hypoglycaemic activities of the experimental herbal samples, help identify more potent indigenous hyp glucosecaemic herbs (in crude ethanolic extract) from the comparative study of the reported experimental results. Expand
Biological activities and medicinal properties of neem (Azadirachta indica)
This review gives a bird’s eye view mainly on the biological activities of some of the neem compounds isolated, pharmacological actions ofThe neem extracts, clinical studies and plausible medicinal applications of neem along with their safety evaluation. Expand
Early post implantation contraceptive effects of a purified fraction of neem (Azadirachta indica) seeds, given orally in rats: possible mechanisms involved.
The results of the present study show that a pure active fraction of neem seeds could be obtained for the purpose of early post implantation contraception when given orally, and its mechanism of action seems to be by activating cell mediated immune reactions. Expand
Anti-inflammatory and antipyretic activities of Azadirachta indica.
Neem tree extract was found to have a pronounced anti-inflammatory effect and a fairly good antipyretic effect and the acute oral toxicity test in mice showed a very low range of approximately 13 g/kg body weight. Expand
Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats.
In stressed rats, AI significantly attenuated the stress-induced suppression of humoral immune response and gastric ulcerogenesis and the possible mechanisms involved in the effects of AI in normal and stressful situations are discussed. Expand
Medicinal Plants: Chemistry and Properties
Medicinal Plants chemistry and Properties , Medicinal Plants chemistry and Properties , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Hypoglycemic activity of Melia azadirachta Linn.(Neem) Indian Journal of Medical Research 1981;74:931-33
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