Corpus ID: 33102458

Antidepressive and antihypertensive effects of MAO-A inhibition: role of N-acetylserotonin. A review.

@article{Oxenkrug1999AntidepressiveAA,
  title={Antidepressive and antihypertensive effects of MAO-A inhibition: role of N-acetylserotonin. A review.},
  author={G. Oxenkrug},
  journal={Neurobiology},
  year={1999},
  volume={7 2},
  pages={
          213-24
        }
}
  • G. Oxenkrug
  • Published 1999
  • Chemistry, Medicine
  • Neurobiology
  • Acute administration of irreversible and reversible selective MAO-A inhibitors and high doses (or chronic administration of low doses) of relatively selective MAO-B inhibitors (but not of highly selective MAO-B inhibitors) suppressed MAO-A activity and stimulated N-acetylation of pineal serotonin into N-acetylserotonin, the immediate precursor of melatonin. Consequent increase of melatonin occurs only in > 21-days-old rats. The effect is strain (spontaneously hypertensive rats > Fisher344N… CONTINUE READING
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