Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC β1 isozyme in rat brain

@article{Dwivedi2002AntidepressantsRP,
  title={Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC $\beta$1 isozyme in rat brain},
  author={Yogesh K. Dwivedi and A. K. Agrawal and H. Rizavi and G. Pandey},
  journal={Neuropharmacology},
  year={2002},
  volume={43},
  pages={1269-1279}
}
In order to examine whether antidepressants mediate their action by interacting with one of the key components of the phosphoinositide (PI) signaling pathway, i.e. PI-specific phospholipase C (PLC), and whether this represents a common mechanism of action of antidepressants, we determined the effects of antidepressants of various classes on PI-PLC activity and on the expression of PLC isozymes in rat brain. It was observed that chronic (21-day) but not acute (1-day) administration with… Expand
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