Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

@article{Mar2000AntidepressantsPE,
  title={Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat},
  author={Adam C. Mar and Emma Spreekmeester and Joseph Rochford},
  journal={Psychopharmacology},
  year={2000},
  volume={150},
  pages={52-60}
}
Rationale: The mechanisms whereby antidepressant drugs exert their therapeutic effects remain unknown. Responses to stressful stimuli are currently thought to contribute to the onset and course of affective disorders. It has been postulated that antidepressants might act by ameliorating response patterns to challenging life events, such as processes of reactivity and/or habituation. Objective: Using the olfactory bulbectomy (OBX) rat model, this study examined the effects of various… CONTINUE READING

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