Antidepressants inhibit human acetylcholinesterase and butyrylcholinesterase activity.

  title={Antidepressants inhibit human acetylcholinesterase and butyrylcholinesterase activity.},
  author={Tatiane C M{\"u}ller and Jo{\~a}o Batista T Rocha and Vera M Morsch and Roseli Tatto Neis and Maria Rosa Schetinger},
  journal={Biochimica et biophysica acta},
  volume={1587 1},
This study examines the effect of the antidepressants fluoxetine, sertraline and amitriptyline on cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)) activities in human serum and erythrocyte membrane (ghost). The concentrations used range from 3 to 60 microM for fluoxetine and amitriptyline and 0.3 to 12 microM for sertraline. At the micromolar range concentration, different classes of antidepressants, including fluoxetine and sertraline (selective serotonin reuptake… CONTINUE READING
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