Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review

  title={Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review},
  author={Wim Verbeeck and Siegfried Tuinier and Geertruida E. Bekkering},
  journal={Advances in Therapy},
IntroductionStimulant medications are the most effective drugs in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and in adults. However, some patients do not respond to this treatment and other patients suffer from adverse effects. Very often there are also comorbid disorders that warrant treatment or there is somatic comorbidity that precludes the prescription of stimulants. As a result, alternative treatments for the treatment of ADHD have been explored, such as… 
An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults
The aggregate literature shows that the stimulants and catecholaminergic nonstimulants investigated had a clinically significant beneficial effect on treating ADHD in adults.
Psychopharmacology and psychotherapy for the treatment of adults with ADHD—a systematic review of available meta-analyses
The available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD, and results suggest that stimulants are effective in decreasing ADHD symptoms on a short-term basis with a medium to large effect size (ES).
Management of attention-deficit hyperactivity disorder in adults: focus on methylphenidate hydrochloride
Methylphenidate hydrochloride, a stimulant that acts through the dopaminergic and adrenergic pathways, has shown more than 75% efficacy in controlling the symptoms of adult ADHD and has shown benefits in preventing substance use disorders in patients with adult ADHD.
Vortioxetine for attention deficit hyperactivity disorder in adults: A randomized, double-blind, placebo-controlled, proof-of-concept study
This randomized, placebo-controlled, proof-of-concept study evaluated the efficacy of a multimodal antidepressant, vortioxetine, in the treatment of ADHD, and found both doses separated from placebo in improving overall patient functioning, as measured by the Sheehan Disability Scale.
Cognitive enhancers for the treatment of ADHD
Guideline for Screening, Diagnosis and Treatment of ADHD in Adults with Substance Use Disorders
Currently there is no guideline for the screening, diagnosis and treatment of adult attention deficit/hyperactivity disorder (ADHD) in patients with a substance use disorder (SUD). The aim was to
Nonstimulant Treatments for ADHD
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.
  • H. Robertson, G. Feng
  • Psychology, Medicine
    Journal of child psychology and psychiatry, and allied disciplines
  • 2011
The strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders are compared, and future directions for the study of these disorders using cutting-edge genetic tools are discussed.
Evaluation of Bupropion and Venlafaxine in Children with ADHD
It is shown that venlafaxine and bupropion are both effective on decreasing symptoms of ADHD and the response rates are the same in the two groups.
TITLE : Bupropion for Adults with Attention Deficit Hyperactivity Disorder : A Review of the Clinical Effectiveness and Harms of Misuse
  • Medicine, Psychology
is an information service for those involved in planning and providing health care in Canada. HTIS responses are based on a limited literature search and are not comprehensive, systematic reviews.


Antidepressants in the treatment of attention-deficit/hyperactivity disorder.
  • C. Popper
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 1997
Antidepressants differ in their effectiveness for treating attention-deficit/hyperactivity disorder (ADHD) in adults and children, and psychostimulants remain the treatment of choice because of their unique effect on attention.
Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder.
Results in adults with ADHD indicate that desipramine is effective in the treatment of ADHD in adults, similar to findings in children and adolescents with ADHD.
Non-Stimulant Treatment of Attention-Deficit/Hyperactivity Disorder
Clinical guidelines for each of these agents, as well as their use in combination with stimulants in comorbid conditions, will be discussed.
Meta-Analysis of the Efficacy of Methylphenidate for Treating Adult Attention-Deficit/Hyperactivity Disorder
Strong support is found for the assertion that MPH is efficacious for treating adult ADHD and provides further assurance to clinicians that the diagnosis of ADHD can be validly applied in adulthood.
Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder.
More research is needed on alternative pharmacological treatments and to further evaluate established therapeutics beyond school-aged Caucasian boys on the efficacy of psychopharmacological agents in attention-deficit hyperactivity disorder.
Present and future pharmacotherapeutic options for adult attention deficit/hyperactivity disorder
  • J. Horrigan
  • Psychology, Medicine
    Expert opinion on pharmacotherapy
  • 2001
The findings from this study have been generalised to adults that also have ADHD, particularly in cases where there is a well-defined longitudinal history dating back to early childhood.
Attention-deficit/hyperactivity disorder in adults: a survey of current practice in psychiatry and primary care.
Data contained within this medical record review suggest that adult ADHD is a substantial source of morbidity in both psychiatric and PCP settings.
Clinical assessment and treatment of attention deficit hyperactivity disorder in adults
  • P. Asherson
  • Psychology, Medicine
    Expert review of neurotherapeutics
  • 2005
The common clinical presentation of ADHD is described and guidelines for the diagnosis and treatment of ADHD in adults are provided, to assist psychiatrists and other adult mental health workers in identifying and treating individuals with adult ADHD.
Reboxetine versus methylphenidate in treatment of children and adolescents with attention deficit-hyperactivity disorder
It is revealed that reboxetine may be beneficial in treatment of ADHD and further studies are required to clarify the potential therapeutic effects on comorbid depression and anxiety and adverse effect profile.