Antidepressants in Inflammatory Bowel Disease: A Systematic Review
@article{Macer2017AntidepressantsII, title={Antidepressants in Inflammatory Bowel Disease: A Systematic Review}, author={Benjamin Macer and Stephanie L. Prady and Antonina Mikocka-Walus}, journal={Inflammatory Bowel Diseases}, year={2017}, volume={23}, pages={534–550} }
Background: Antidepressants are commonly used to treat symptoms of anxiety and depression in inflammatory bowel disease (IBD. [] Key Method Results: Fifteen eligible studies included in the review (1 randomized controlled trial, 2 cohorts, 1 case–control, 1 cross-sectional survey, 1 qualitative, 2 audits, 1 case series, and 6 case reports) examined a range of antidepressants. Twelve studies suggested that antidepressants have a positive impact on IBD course. Nine studies reported anxiety and depression as…
52 Citations
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.
- Psychology, MedicineThe Cochrane database of systematic reviews
- 2019
The efficacy and safety of antidepressants for treating anxiety and depression in IBD, and the effects of antidepressants on quality of life (QoL) and managing disease activity in I BD are assessed.
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- Psychology, MedicineJournal of psychosomatic research
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Venlafaxine has a significantly beneficial effect on QoL, IBD activity, and mental health in patients with IBD with comorbid anxious or depressive symptoms.
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
- Medicine, PsychologyCanadian journal of gastroenterology & hepatology
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Antidepressants may have some beneficial effects on the natural history of IBD, but larger studies with longer follow-up are required to determine whether these effects are limited to patients with abnormal mood.
Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression
- Medicine, PsychologyGut
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Patients with a history of depression were more likely to be diagnosed with IBD and antidepressant treatments were selectively protective for Crohn’s disease and UC, which may impact counselling and management of depression and IBD.
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Bidirectional effects of the brain–gut axis are present in IBD and may influence both the natural history of the disease and psychological health.
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Evidence on sex-based differences in depression pathogenesis and the effect of depression on various factors associated with IBD that affect women's lives, including sexual dysfunction, body image dissatisfaction, fertility, and overall quality of life is presented.
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Monitoring for mood disorders should become a part of the multi-disciplinary and holistic approach to patients with IBD, based on current literature searched in PubMed.
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In this nationwide study, antidepressant use was found to be beneficial on the disease course among patients with UC and CD, particularly in patients with no use of antidepressants before IBD onset.
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- Psychology, MedicineInflammatory bowel diseases
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Symptoms of depression and anxiety are associated with disease activity in IBD over time and reducing these symptoms should be incorporated into the management of IBD.
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