Antidepressants in Inflammatory Bowel Disease: A Systematic Review

@article{Macer2017AntidepressantsII,
  title={Antidepressants in Inflammatory Bowel Disease: A Systematic Review},
  author={Benjamin Macer and S. Prady and A. Mikocka-Walus},
  journal={Inflammatory Bowel Diseases},
  year={2017},
  volume={23},
  pages={534–550}
}
Background: Antidepressants are commonly used to treat symptoms of anxiety and depression in inflammatory bowel disease (IBD. [...] Key Method Results: Fifteen eligible studies included in the review (1 randomized controlled trial, 2 cohorts, 1 case–control, 1 cross-sectional survey, 1 qualitative, 2 audits, 1 case series, and 6 case reports) examined a range of antidepressants. Twelve studies suggested that antidepressants have a positive impact on IBD course. Nine studies reported anxiety and depression as…Expand

Paper Mentions

Interventional Clinical Trial
Inflammatory bowel disease (IBD) patients commonly suffer from disturbed psychosocial functioning and poor quality of life compared to other chronic disease patients. Clinicians… Expand
ConditionsInflammatory Bowel Diseases
InterventionBehavioral
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.
TLDR
The efficacy and safety of antidepressants for treating anxiety and depression in IBD, and the effects of antidepressants on quality of life (QoL) and managing disease activity in I BD are assessed. Expand
Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review.
TLDR
The results suggest that psychiatric treatment should be implemented in IBD care, however, further studies are needed to confirm the findings of this systematic review. Expand
The Effect of Antidepressants on the Course of Inflammatory Bowel Disease
TLDR
Antidepressants may have some beneficial effects on the natural history of IBD, but larger studies with longer follow-up are required to determine whether these effects are limited to patients with abnormal mood. Expand
Beyond Efficacy: The Acceptability of Antidepressant Treatment to Patients with Inflammatory Bowel Disease.
TLDR
The evidence suggests that adverse effects may be common in patients with IBD treated with antidepressants, creating an important barrier to mental and physical recovery from anxiety, depression, and their potential sequelae. Expand
Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression
TLDR
Patients with a history of depression were more likely to be diagnosed with IBD and antidepressant treatments were selectively protective for Crohn’s disease and UC, which may impact counselling and management of depression and IBD. Expand
The emerging role of mood disorders in inflammatory bowel diseases.
TLDR
Monitoring for mood disorders should become a part of the multi-disciplinary and holistic approach to patients with IBD, based on current literature searched in PubMed. Expand
The Influence of Antidepressants on the Disease Course Among Patients With Crohn’s Disease and Ulcerative Colitis—A Danish Nationwide Register–Based Cohort Study
TLDR
In this nationwide study, antidepressant use was found to be beneficial on the disease course among patients with UC and CD, particularly in patients with no use of antidepressants before IBD onset. Expand
The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time.
TLDR
Symptoms of depression and anxiety are associated with disease activity in IBD over time and reducing these symptoms should be incorporated into the management of IBD. Expand
Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation?
TLDR
This study goes further, suggesting that assertive pharmacological treatment of depression could reduce the incidence of IBD altogether, and draws the authors’ attention to an important limitation of its current design that tempers its conclusions. Expand
Managing Pain and Psychosocial Care in IBD: a Primer for the Practicing Gastroenterologist
TLDR
Despite the significant limitations of research, particularly lack of clinical trials examining behavioral and pharmacotherapy interventions in IBD, effective treatments exist and are best utilized in an integrated care setting. Expand
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