Antidepressants in Inflammatory Bowel Disease: A Systematic Review

@article{Macer2017AntidepressantsII,
  title={Antidepressants in Inflammatory Bowel Disease: A Systematic Review},
  author={Benjamin Macer and Stephanie L. Prady and Antonina Mikocka-Walus},
  journal={Inflammatory Bowel Diseases},
  year={2017},
  volume={23},
  pages={534–550}
}
Background: Antidepressants are commonly used to treat symptoms of anxiety and depression in inflammatory bowel disease (IBD. [] Key Method Results: Fifteen eligible studies included in the review (1 randomized controlled trial, 2 cohorts, 1 case–control, 1 cross-sectional survey, 1 qualitative, 2 audits, 1 case series, and 6 case reports) examined a range of antidepressants. Twelve studies suggested that antidepressants have a positive impact on IBD course. Nine studies reported anxiety and depression as…
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51 Citations
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51 Citations

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

The efficacy and safety of antidepressants for treating anxiety and depression in IBD, and the effects of antidepressants on quality of life (QoL) and managing disease activity in I BD are assessed.

Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review.

Venlafaxine as an Adjuvant Therapy for Inflammatory Bowel Disease Patients With Anxious and Depressive Symptoms: A Randomized Controlled Trial

Venlafaxine has a significantly beneficial effect on QoL, IBD activity, and mental health in patients with IBD with comorbid anxious or depressive symptoms.

The Effect of Antidepressants on the Course of Inflammatory Bowel Disease

Antidepressants may have some beneficial effects on the natural history of IBD, but larger studies with longer follow-up are required to determine whether these effects are limited to patients with abnormal mood.

Beyond Efficacy: The Acceptability of Antidepressant Treatment to Patients with Inflammatory Bowel Disease.

The evidence suggests that adverse effects may be common in patients with IBD treated with antidepressants, creating an important barrier to mental and physical recovery from anxiety, depression, and their potential sequelae.

Bidirectional brain–gut axis effects influence mood and prognosis in IBD: a systematic review and meta-analysis

Bidirectional effects of the brain–gut axis are present in IBD and may influence both the natural history of the disease and psychological health.

The emerging role of mood disorders in inflammatory bowel diseases.

Monitoring for mood disorders should become a part of the multi-disciplinary and holistic approach to patients with IBD, based on current literature searched in PubMed.

The Influence of Antidepressants on the Disease Course Among Patients With Crohn’s Disease and Ulcerative Colitis—A Danish Nationwide Register–Based Cohort Study

In this nationwide study, antidepressant use was found to be beneficial on the disease course among patients with UC and CD, particularly in patients with no use of antidepressants before IBD onset.

The Relationship Between Symptoms of Depression and Anxiety and Disease Activity in IBD Over Time.

Symptoms of depression and anxiety are associated with disease activity in IBD over time and reducing these symptoms should be incorporated into the management of IBD.

Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation?

This study goes further, suggesting that assertive pharmacological treatment of depression could reduce the incidence of IBD altogether, and draws the authors’ attention to an important limitation of its current design that tempers its conclusions.
...

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