Antidepressants for functional gastrointestinal syndromes

@article{Clouse1994AntidepressantsFF,
  title={Antidepressants for functional gastrointestinal syndromes},
  author={Dr. Ray E. Clouse},
  journal={Digestive Diseases and Sciences},
  year={1994},
  volume={39},
  pages={2352-2363}
}
Antidepressant agents have been suggested as treatments for functional gastrointestinal syndromes since the early 1960s (1). Their efficacy has been demonstrated through anecdotal reports and a small number of controlled studies, but the best candidates for treatment remain unknown. This paper describes the rationale for trying antidepressants for the functional disorders, the outcome of reported studies in several of the syndromes, and a discussion of potential modes of action in these… CONTINUE READING
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