Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor

Abstract

Antidepressants are commonly supposed to enhance serotonergic and/or noradrenergic neurotransmission by inhibition of neurotransmitter reuptake through binding to the respective neurotransmitter transporters or through inhibition of the monoamine oxidase. Using the concentration-clamp technique and measurements of intracellular Ca2+, we demonstrate that… (More)
DOI: 10.1038/sj.mp.4001314

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