• DOI:10.15406/JABB.2017.3.00082
• Corpus ID: 28388023

Antidepressants: mechanism of action, toxicity and possible amelioration

@inproceedings{Gaur2017AntidepressantsMO,
  title={Antidepressants: mechanism of action, toxicity and possible amelioration},
  author={Khushboo Gaur and Balkishan Sharma},
  year={2017}
}

• Khushboo Gaur, B. Sharma
• Published 1 September 2017
• Biology, Computer Science

Depression being a state of sadness may be defined as a psychoneurotic disorder characterised by mental and functional activity sadness reduction in activity difficulty in thinking loss of concentration perturbations in appetite sleeping and feelings of dejection hopelessness and generation of suicidal tendencies It is a common and recurrent disorder causing significant morbidity and mortality worldwide The antidepressant compounds used against depression are reported to be used also for treating pain anxiety syndromes etc They have been grouped in five different categories such as nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp I nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Tricyclic antidepressants TCAs nbsp nbsp nbsp nbsp nbsp nbsp II nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Selective serotonin reuptake inhibitors SSRIs nbsp nbsp nbsp nbsp III nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Monoamine oxidase inhibitors MAOIs nbsp nbsp nbsp nbsp IV nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Serotonin norepinephrine reuptake inhibitor SNRI and nbsp nbsp nbsp nbsp nbsp nbsp V nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Non TCA antidepressants based on their mode of action Most of the antidepressants have been reported to possess adverse effects on the health of users The present review article focuses on an updated current of antidepressants their mechanism of actions pathophysiology of these compounds their side effects and the strategies to combat the drug induced toxicity An account of phytochemicals found to be acting as antidepressant is also included