Antidepressants, alcohol and psychomotor performance

@article{Tiller1990AntidepressantsAA,
  title={Antidepressants, alcohol and psychomotor performance},
  author={John W. G. Tiller},
  journal={Acta Psychiatrica Scandinavica},
  year={1990},
  volume={82}
}
  • J. Tiller
  • Published 1990
  • Medicine
  • Acta Psychiatrica Scandinavica
The acute psychomotor effects of moclobemide, a reversible inhibitor of MAO‐A antidepressant (100 and 300 mg) compared with amitriptyline (25 and 75 mg) showed that moclobemide caused no significant impairment in contrast with amitriptyline, which caused significant impairment at both doses. Two other studies are reviewed. One study reported the acute effects of moclobemide (100 and 300 mg), trazodone (100 mg), placebo, and alcohol (0.5 g/kg) or placebo in an elderly group: moclobemide caused… Expand
27 Citations
The effects of brofaromine alone and in conjunction with alcohol on cognitive function, psychomotor performance, mood and sleep in healthy volunteers
Brofaromine is a novel antidepressant that functions by the inhibition of the A form of monoamine oxidase (MAO). This inhibition is reversible, making brofaromine both pharmacologically andExpand
Behavioural toxicity of antidepressants with particular reference to moclobemide
TLDR
On the whole moclobemide has been found to be free from any behavioural toxicity likely to interfere with the well-being of patients or their performance of the tasks of everyday living. Expand
Human psychopharmacology of second generation antidepressants.
TLDR
Data presented in this thesis suggest that there are differences in the extent to which these drugs affect performance, which should be taken into consideration in the management of depression in ambulant outpatients. Expand
Effects of single and multiple doses of a new reversible MAO‐A inhibitor, befloxatone, on psychomotor performance and memory in healthy subjects
The effects on memory, psychomotor performance and mood of two dosage regimens of befloxatone, a new reversible and selective MAO‐A inhibitor were assessed in a randomized, double‐blind, cross‐over,Expand
Meta-Analysis of the Reversible Inhibitors of Monoamine Oxidase Type A Moclobemide and Brofaromine for the Treatment of Depression
TLDR
A series of meta-analyses of studies of the two most widely researched RIMAs, moclobemide (MOC; Aurorex) and brofaromine (BRO) confirm that both BRO and MOC are as effective as the tricyclic antidepressants, and they are better tolerated. Expand
Nefazodone: A Review of Its Neurochemical Mechanisms, Pharmacokinetics, and Therapeutic Use in Major Depressive Disorder
TLDR
Since nefazodone is an effective antidepressant with a low incidence of serious adverse effects, it may be particularly useful in major depressive disorder patients who are intolerant of the anticholinergic or serotonergic side effects of other antidepressants, or who do not respond to treatment with other antidepressant agents. Expand
A review of the reversible MAO‐A inhibitor moclobemide in geriatric patients
TLDR
A comparison of the relevant literature shows that moclobemide has advantages over other, classic, antidepressants because of better tolerability, fewer side effects and interactions, shorter latency of effect, and lower toxicity. Expand
Acute and chronic effects of clomipramine on isolation-induced aggression in male mice
The behavioral effects of clomipramine were studied on an ethopharmacological model of aggression. A range of low doses (similar to those used in clinical practice: 1.5, 3, and 6 mg/kg) and a higherExpand
Investigation of the effects of moclobemide in chronic ethanol feeding rats.
TLDR
The results suggest that there has been no adverse interaction between ethanol and moclobemide. Expand
Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects.
TLDR
Analysis of variance showed that continuous attention test (CAT), critical flicker fusion threshold (CFFT), decision making test (DMT) and paired word association (PWA) were significantly impaired with amitriptyline compared with minaprine and placebo. Expand
...
1
2
3
...

References

SHOWING 1-9 OF 9 REFERENCES
Effects of zimeldine and other antidepressants on skilled performance: a comprehensive review
TLDR
The effects of zimeldine on psychomotor skills have already been extensively investigated, and it has been shown to be without stimulant or sedative effects, and there does not appear to be any additive effect between zIMEldine and ethanol. Expand
An evaluation of possible interactions between ethanol and trazodone or amitriptyline.
TLDR
Ethanol alone impaired manual dexterity, increased drowsiness, reduced 'clear headedness' and also tended to reduce feelings of aggression and in combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity which was further impaired. Expand
The effects of paroxetine and other antidepressants in combination with alcohol on psychomotor activity related to car driving
TLDR
In contrast to amitriptyline, mianserin, and trazodone, paroxetine showed little psychomotor impairment or sedative activity and did not interact with alcohol. Expand
Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving
TLDR
It seems as if doxepin and amitriptyline but not nortriptylines or chlorimipramine, in combination with 0.5 gm/kg of alcohol, may be especially dangerous in driving. Expand
The psychomotor effects of single and repeated doses of hypnotic benzodiazepines.
TLDR
There is minimal impairment with low dose hypnotic drugs and a need to individualize treatment and the difficulties in performing adequately controlled psychopharmacological studies at low doses are highlighted. Expand
A sequential double-blind controlled study of moclobemide and diazepam in patients with atypical depression.
A double-blind controlled study comparing moclobemide and diazepam in patients with atypical depression was carried out. Statistical comparison of the 14 pairs completing 4 weeks showed thatExpand
A sequential double‐blind controlled study of moclobemide and mianserin in elderly depressed patients
Moclobemide was compared with mianserin in a double‐blind controlled study in elderly depressed patients. Sequential analysis of 11 pairs of patients found no significant difference between the drugsExpand
Effects of the tetracyclic antidepressant pirlindole on sensorimotor performance and subjective condition in comparison to imipramine and during interaction of ethanol.
TLDR
The effects of pirlindole proved to be unaffected by ethanol, and ratings of subjective feelings and measurements of sensorimotor performance of the pirlINDole-treated group did not differ from those of the placebo group. Expand
Effect of tricyclic antidepressants on skilled performance: a comprehensive review
  • Acta Psychiatr Scand
  • 1989