Antidepressants, alcohol and psychomotor performance

  title={Antidepressants, alcohol and psychomotor performance},
  author={John W. G. Tiller},
  journal={Acta Psychiatrica Scandinavica},
  • J. Tiller
  • Published 1990
  • Medicine
  • Acta Psychiatrica Scandinavica
The acute psychomotor effects of moclobemide, a reversible inhibitor of MAO‐A antidepressant (100 and 300 mg) compared with amitriptyline (25 and 75 mg) showed that moclobemide caused no significant impairment in contrast with amitriptyline, which caused significant impairment at both doses. Two other studies are reviewed. One study reported the acute effects of moclobemide (100 and 300 mg), trazodone (100 mg), placebo, and alcohol (0.5 g/kg) or placebo in an elderly group: moclobemide caused… Expand
27 Citations
The effects of brofaromine alone and in conjunction with alcohol on cognitive function, psychomotor performance, mood and sleep in healthy volunteers
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Nefazodone: A Review of Its Neurochemical Mechanisms, Pharmacokinetics, and Therapeutic Use in Major Depressive Disorder
Since nefazodone is an effective antidepressant with a low incidence of serious adverse effects, it may be particularly useful in major depressive disorder patients who are intolerant of the anticholinergic or serotonergic side effects of other antidepressants, or who do not respond to treatment with other antidepressant agents. Expand
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Acute and chronic effects of clomipramine on isolation-induced aggression in male mice
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The results suggest that there has been no adverse interaction between ethanol and moclobemide. Expand
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The effects of zimeldine on psychomotor skills have already been extensively investigated, and it has been shown to be without stimulant or sedative effects, and there does not appear to be any additive effect between zIMEldine and ethanol. Expand
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Ethanol alone impaired manual dexterity, increased drowsiness, reduced 'clear headedness' and also tended to reduce feelings of aggression and in combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity which was further impaired. Expand
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Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving
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The psychomotor effects of single and repeated doses of hypnotic benzodiazepines.
There is minimal impairment with low dose hypnotic drugs and a need to individualize treatment and the difficulties in performing adequately controlled psychopharmacological studies at low doses are highlighted. Expand
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A double-blind controlled study comparing moclobemide and diazepam in patients with atypical depression was carried out. Statistical comparison of the 14 pairs completing 4 weeks showed thatExpand
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Moclobemide was compared with mianserin in a double‐blind controlled study in elderly depressed patients. Sequential analysis of 11 pairs of patients found no significant difference between the drugsExpand
Effects of the tetracyclic antidepressant pirlindole on sensorimotor performance and subjective condition in comparison to imipramine and during interaction of ethanol.
The effects of pirlindole proved to be unaffected by ethanol, and ratings of subjective feelings and measurements of sensorimotor performance of the pirlINDole-treated group did not differ from those of the placebo group. Expand
Effect of tricyclic antidepressants on skilled performance: a comprehensive review
  • Acta Psychiatr Scand
  • 1989