Antidepressant withdrawal-induced activation (hypomania and mania): Mechanism and theoretical significance

  title={Antidepressant withdrawal-induced activation (hypomania and mania): Mechanism and theoretical significance},
  author={Steven C. Dilsaver and John F. Greden},
  journal={Brain Research Reviews},
Electrocortical and behavioral arousal are separate phenomena subserved by different neural substrata operating in parallel. A comprehensive theory of 'activation' must take into account the relationships between the electrical and behavioral activating systems. In pathological or experimentally induced states paradoxes, resolvable by a theory positing functional interaction between these systems, arise. EEG arousal is directly mediated, in both the waking and sleeping state, by cholinergic… CONTINUE READING


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