Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience.

@article{Clouse1994AntidepressantTI,
  title={Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience.},
  author={Ray E. Clouse and Patrick J. Lustman and R A Geisman and David H. Alpers},
  journal={Alimentary pharmacology & therapeutics},
  year={1994},
  volume={8 4},
  pages={409-16}
}
BACKGROUND Antidepressant agents may have a therapeutic role in functional gastroenterologic disorders, but controlled investigations in irritable bowel syndrome (IBS) have not provided satisfactory practice recommendations. To help with future study design, we reviewed a five-year clinical experience with antidepressant agents in out-patients with IBS. METHODS Presenting features, treatment course, and clinical outcome were determined from a chart review of 138 patients attending a… CONTINUE READING