Antidepressant response and the serotonin transporter gene-linked polymorphic region.

  title={Antidepressant response and the serotonin transporter gene-linked polymorphic region.},
  author={Matthew J Taylor and Srijan Sen and Zubin Bhagwagar},
  journal={Biological psychiatry},
  volume={68 6},
BACKGROUND The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been proposed as a predictor of antidepressant response. Insertion or deletion of a 44-base pair-long region gives rise to short "S" and long "L" forms of the promoter region, the "S" form being associated with reduced serotonin transporter expression. METHODS A systematic review and meta-analysis was performed to clarify the effect of 5-HTTLPR on antidepressant response and remission rates. Data were obtained… CONTINUE READING

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Polymorphisms in the SLC 6 A 4 and HTR 2 A genes influence treatment outcome following antidepressant therapy

  • MJ Wilkie, G Smith, RK Day, K Matthews, D Smith, D Blackwood
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