Antidepressant medication use and trajectories of fasting plasma glucose, glycated haemoglobin, β-cell function and insulin sensitivity: a 9-year longitudinal study of the D.E.S.I.R. cohort.

@article{Silva2015AntidepressantMU,
  title={Antidepressant medication use and trajectories of fasting plasma glucose, glycated haemoglobin, β-cell function and insulin sensitivity: a 9-year longitudinal study of the D.E.S.I.R. cohort.},
  author={Marine Azevedo Da Silva and Aline Dugravot and Beverley Balkau and Ronan Roussel and Fr{\'e}d{\'e}ric Fumeron and Alexis Elbaz and Marianne Canonico and Archana Singh-Manoux and Hermann Nabi},
  journal={International journal of epidemiology},
  year={2015},
  volume={44 6},
  pages={1927-40}
}
BACKGROUND Use of antidepressants is seen to be a risk factor for type 2 diabetes, even though the underlying mechanisms remain unclear. We examined whether antidepressant use was associated with change in fasting plasma glucose, glycated haemoglobin (HbA1c), β-cell function (HOMA2-%B) and insulin sensitivity (HOMA2-%S) over time. METHODS Participants in the French D.E.S.I.R. cohort study included over 4700 men (48.1%) and women, free of diabetes, aged 30-65 years at baseline in 1994-96 (D.E… CONTINUE READING

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