Antidepressant mechanism of ketamine: perspective from preclinical studies

  title={Antidepressant mechanism of ketamine: perspective from preclinical studies},
  author={Lisa Scheuing and Chi-Tso Chiu and Hsiao-Mei Liao and D. -M. Chuang},
  booktitle={Front. Neurosci.},
A debilitating mental disorder, major depressive disorder is a leading cause of global disease burden. Existing antidepressant drugs are not adequate for the majority of depressed patients, and large clinical studies have demonstrated their limited efficacy and slow response onset. Growing evidence of low-dose ketamine's rapid and potent antidepressant effects offers strong potential for future antidepressant agents. However, ketamine has considerable drawbacks such as its abuse potential… CONTINUE READING
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