Antidepressant-like responses to lithium in genetically diverse mouse strains.

  title={Antidepressant-like responses to lithium in genetically diverse mouse strains.},
  author={Adem Can and Robert A Blackwell and Sean C. Piantadosi and David T Dao and Kelley C O'Donnell and Todd D. Gould},
  journal={Genes, brain, and behavior},
  volume={10 4},
A mood stabilizing and antidepressant response to lithium is only found in a subgroup of patients with bipolar disorder and depression. Identifying strains of mice that manifest differential behavioral responses to lithium may assist in the identification of genomic and other biologic factors that play a role in lithium responsiveness. Mouse strains were tested in the forced swim test (FST), tail suspension test (TST) and open-field test after acute and chronic systemic and… CONTINUE READING

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