Antidepressant-like properties of zinc in rodent forced swim test

  title={Antidepressant-like properties of zinc in rodent forced swim test},
  author={Bernadetta Kroczka and Piotr Brański and Agnieszka Palucha and Andrzej Pilc and Gabriel Nowak},
  journal={Brain Research Bulletin},
The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO4) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in this test with zinc and imipramine at their ineffective doses (1 and 5 mg/kg, respectively) induced a statistically significant effect in rats. The doses active in the forced swim test reduced (in mice… CONTINUE READING
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