Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats

  title={Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats},
  author={W. Carlezon and Stephen D. Mague and A. Parow and A. Stoll and P. Renshaw},
  journal={Biological Psychiatry},
  • W. Carlezon, Stephen D. Mague, +2 authors P. Renshaw
  • Published 2005
  • Medicine
  • Biological Psychiatry
  • BACKGROUND Brain phospholipid metabolism and membrane fluidity may be involved in the pathophysiology of mood disorders. We showed previously that cytidine, which increases phospholipid synthesis, has antidepressant-like effects in the forced swim test (FST) in rats, a model used in depression research. Because cytidine and uridine both stimulate synthesis of cytidine 5'-diphosphocholine (CDP-choline, a critical substrate for phospholipid synthesis), we examined whether uridine would also… CONTINUE READING
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