• DOI:10.1016/j.biopsych.2004.11.038
Corpus ID: 1834258

Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats

@article{Carlezon2005AntidepressantlikeEO,
  title={Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats},
  author={W. Carlezon and Stephen D. Mague and A. Parow and A. Stoll and P. Renshaw},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={343-350}
}

W. Carlezon, Stephen D. Mague, +2 authors P. Renshaw

Published 2005

Medicine

Biological Psychiatry

BACKGROUND Brain phospholipid metabolism and membrane fluidity may be involved in the pathophysiology of mood disorders. We showed previously that cytidine, which increases phospholipid synthesis, has antidepressant-like effects in the forced swim test (FST) in rats, a model used in depression research. Because cytidine and uridine both stimulate synthesis of cytidine 5'-diphosphocholine (CDP-choline, a critical substrate for phospholipid synthesis), we examined whether uridine would also… CONTINUE READING

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