Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats.

@article{RojasCorrales2002AntidepressantlikeEO,
  title={Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats.},
  author={Mar{\'i}a Olga Rojas-Corrales and Esther Berrocoso and Juan Gibert-Rahola and Juan Antonio Mic{\'o}},
  journal={Life sciences},
  year={2002},
  volume={72 2},
  pages={143-52}
}
Affective states are regulated mainly by serotonin and noradrenaline. However the opioid system has been also related to antidepressant-induced mood improvement, and the mu-opioid receptor has been involved in affective responses to a sustained painful stimulus. Similarly, antidepressant drugs induce an antinociceptive effect via both the monoaminergic and opioid systems, probably involving sensorial and affective dimensions of pain. The aim of this study was to test three opiate analgesics… CONTINUE READING

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