Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice

@article{Wang2014AntidepressantlikeEO,
  title={Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice},
  author={Chuang Wang and Jianrui Zhang and Yang Lu and Peipei Lin and Tonghe Pan and Xin Zhao and Aiming Liu and Qinwen Wang and Wen-hua Zhou and Han Zhang},
  journal={Metabolic Brain Disease},
  year={2014},
  volume={29},
  pages={673-682}
}
Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior. However, causal links among these actions have not been established. In the present study, mice were evaluated for the effects of etazolate… CONTINUE READING

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