Antidepressant-like effects of p-synephrine in mouse models of immobility tests

@article{Song1996AntidepressantlikeEO,
  title={Antidepressant-like effects of p-synephrine in mouse models of immobility tests},
  author={Dong-Keun Song and Hong-Won Suh and Jun-Sub Jung and Myung Bok Wie and Kun Ho Son and Yung-Hi Kim},
  journal={Neuroscience Letters},
  year={1996},
  volume={214},
  pages={107-110}
}
We studied the effects of p-synephrine on the immobility behaviors and on the spontaneous motor activity in mice. p-Synephrine at oral doses from 1 to 10 mg/kg significantly decreased the duration of immobility in the tail suspension test and the forced swimming test in mice. At 30 mg/kg, the duration of immobility was returned to control values in both tests. Subcutaneous administration of prazosin hydrochloride (62.5 micrograms/kg), an alpha 1 adrenoceptor antagonist, blocked the p-synephrine… Expand
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