Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain

@article{Mueller2018AntidepressantlikeEO,
  title={Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain},
  author={Paul L. Mueller and Carolyn E. Pritchett and Tyler N. Wiechman and Alevtina Zharikov and Andras Hajnal},
  journal={Brain Research Bulletin},
  year={2018},
  volume={143},
  pages={27-35}
}
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Results indicate that IGF-I down regulates glial activation and induces expression of an endogenous growth factor that shares anti-depressant activity, which parallel its ability to diminish depressive-like behavior.
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