Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice

@article{Mineur2015AntidepressantlikeEO,
  title={Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice},
  author={Yann S. Mineur and Matthew P. Bentham and Wen-liang Zhou and Margreet E. Plantenga and Sherry A. McKee and Marina R. Picciotto},
  journal={Psychopharmacology},
  year={2015},
  volume={232},
  pages={3539-3549}
}
The a2A-noradrenergic agonist guanfacine can decreases stress-induced smoking in female, but not male, human smokers. It is not known whether these effects are due to effects on mood regulation and/or result from nicotinic-cholinergic interactions. The objective of the study was to determine whether there are sex differences in the effect of guanfacine in tests of anxiolytic and antidepressant efficacy in mice at baseline and in a hypercholinergic model of depression induced by the… CONTINUE READING
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