Antidepressant-like effects of dopamine agonists in an animal model of depression

  title={Antidepressant-like effects of dopamine agonists in an animal model of depression},
  author={Richard Muscat and Mariusz Papp and Paul Willner},
  journal={Biological Psychiatry},
Chronic exposure to mild unpredictable stress (CMS) has previously been found to cause an antidepressant-reversible decrease in the consumption of palatable sweet solutions. There is evidence that the effect of antidepressants in this model is mediated by an increase in transmission at dopamine (DA) synpases. The present study investigated whether another treatment known to increase the functional responsiveness of DA systems, intermittent administration of DA agonists, would have… CONTINUE READING

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