Antidepressant-like effects of cytidine in the forced swim test in rats

@article{Carlezon2002AntidepressantlikeEO,
  title={Antidepressant-like effects of cytidine in the forced swim test in rats},
  author={William A. Carlezon and Andrea M. Pliakas and Aimee M. Parow and Michael J. Detke and Bruce M Cohen and Perry F. Renshaw},
  journal={Biological Psychiatry},
  year={2002},
  volume={51},
  pages={882-889}
}
BACKGROUND Altered brain phospholipid metabolism may be involved in the pathophysiology of cocaine dependence and mood disorders. Evidence suggests that citicoline, a rate-limiting metabolite for phospholipid synthesis, reduces cocaine craving in human addicts. Because antidepressants can reduce cocaine craving, we explored in rats the possibility that citicoline has antidepressant effects. We also tested the primary metabolites of citicoline, cytidine and choline. METHODS We examined if… Expand
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