Antidepressant-like effects of cytidine in the forced swim test in rats

@article{Carlezon2002AntidepressantlikeEO,
  title={Antidepressant-like effects of cytidine in the forced swim test in rats},
  author={William A. Carlezon and Andrea M. Pliakas and Aimee M. Parow and Michael J. Detke and Bruce M. Cohen and Perry F. Renshaw},
  journal={Biological Psychiatry},
  year={2002},
  volume={51},
  pages={882-889}
}

Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats

TLDR
SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects.

Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

TLDR
Findings are consistent with the hypothesis that CREB-mediated induction of dynorphin in the NAc “triggers” immobility behavior in the FST and raise the possibility that κ-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects.

Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.

TLDR
Findings are consistent with the hypothesis that CREB-mediated induction of dynorphin in the NAc "triggers" immobility behavior in the FST and raise the possibility that kappa-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects.

Sex-related differential response to clomipramine treatment in a rat model of depression

TLDR
In this animal model of depression, chronic clomipramine treatment attenuated baseline sex differences in the phenotype while maintaining or intensifying the sex differentiation in the serotonergic endophenotype.

Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats

...

References

SHOWING 1-10 OF 39 REFERENCES

Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report

TLDR
Preliminary data are encouraging and suggest that citicoline warrants further study as a promising potential treatment for cocaine abuse and dependence that is devoid of side effects.

Depression: a new animal model sensitive to antidepressant treatments

TLDR
Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

TLDR
Elevated CREB expression increased immobility in the FST, an effect that is opposite to that caused by standard antidepressants and is consistent with a link between CREB and dysphoria.

Effects of cholinomimetics, cholinolytics and atypical antidepressants in the behavioral despair test in the rat.

The effect of some cholinolytics, cholinomimetics and atypical antidepressants on behavior of rats forced to swim (in the "behavioral despair test") was investigated. In addition, the relation

Desipramine facilitation of initial cocaine abstinence.

TLDR
It is indicated that desipramine is an effective general treatment, for this first treatment stage, in actively cocaine-dependent outpatients.

Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline.

  • G. Weiss
  • Biology, Chemistry
    Life sciences
  • 1995

Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine.

TLDR
The data suggest that true drug response to fluoxetine treatment in depression may be associated with an increase in choline-creatine ratios in the basal ganglia.