Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.

@article{Veerakumar2014AntidepressantlikeEO,
  title={Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.},
  author={Avin Veerakumar and Collin Challis and Preetika Gupta and Jennifer Da and Aseem Upadhyay and Sheryl G. Beck and Olivier Berton},
  journal={Biological psychiatry},
  year={2014},
  volume={76 3},
  pages={203-12}
}
BACKGROUND Cortical deep brain stimulation (DBS) is a promising therapeutic option for treatment-refractory depression, but its mode of action remains enigmatic. Serotonin (5-HT) systems are engaged indirectly by ventromedial prefrontal cortex (vmPFC) DBS. Resulting neuroplastic changes in 5-HT systems could thus coincide with the long-term therapeutic activity of vmPFC DBS. METHODS We tested this hypothesis by evaluating the antidepressant-like activity of vmPFC DBS in the chronic social… CONTINUE READING