Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.

  title={Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.},
  author={S{\'e}verine Farley and Kalliopi Apazoglou and Jeffrey M. Witkin and Bruno Giros and Eleni Th Tzavara},
  journal={The international journal of neuropsychopharmacology},
  volume={13 9},
Enhancement of AMPA receptor (AMPAR) function has emerged as a novel strategy for treatment of depression. Nevertheless, studies on AMPAR function in chronic animal models used to predict antidepressant efficacy are surprisingly lacking. We investigated the role of AMPARs in antidepressant action in an unpredictable chronic mild stress (UCMS) model in BALB/c mice. After 3 wk of UCMS, BALB/c mice developed a number of depressive-like behaviours that were successfully prevented by fluoxetine (20… CONTINUE READING

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