Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.

@article{Farley2010AntidepressantlikeEO,
  title={Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.},
  author={S{\'e}verine Farley and Kalliopi Apazoglou and Jeffrey M. Witkin and Bruno Giros and Eleni Th Tzavara},
  journal={The international journal of neuropsychopharmacology},
  year={2010},
  volume={13 9},
  pages={1207-18}
}
Enhancement of AMPA receptor (AMPAR) function has emerged as a novel strategy for treatment of depression. Nevertheless, studies on AMPAR function in chronic animal models used to predict antidepressant efficacy are surprisingly lacking. We investigated the role of AMPARs in antidepressant action in an unpredictable chronic mild stress (UCMS) model in BALB/c mice. After 3 wk of UCMS, BALB/c mice developed a number of depressive-like behaviours that were successfully prevented by fluoxetine (20… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

Neuropharmacology • 2001
View 7 Excerpts
Highly Influenced

AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008
View 1 Excerpt

AMPA receptors in the therapeutic management of depression.

CNS & neurological disorders drug targets • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…