Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression

@article{Overstreet2004AntidepressantlikeEO,
  title={Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression},
  author={David H. Overstreet and Joseph J. Hlavka and John P. Feighner and Gabriela Valente Nicolau and Jeffrey Stephen Freed},
  journal={Psychopharmacology},
  year={2004},
  volume={175},
  pages={303-309}
}
BackgroundNemifitide is a novel peptide analog of melanocyte-inhibiting factor (MIF) that has been reported to relieve depressive symptoms in a very short period.ObjectivesThe Flinders Sensitive Line (FSL) rat, a genetic animal model of depression with innate exaggerated immobility in the forced swim test, was used to obtain more detailed information about the antidepressant-like effects of nemifitide.MethodsThe FSL rats were treated chronically with various doses of nemifitide or reference… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Chemistry, pharmacology and clinical studies of nemifitide, a novel antidepressant peptide

JJ Hlavka, JP Feighner, +3 authors L Sverdlov
  • Drugs Fut (Suppl
  • 2002
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Anti-immobility effects of a melatonin receptor agonist, but not antagonist, in a genetic animal model of depression

DH Overstreet, O Pucilowski, M-C Rettori, P Delagrange, B Guardiola-Lemaitre
  • NeuroReport
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The flinders sensitive line rats: A genetic animal model of depression

  • Neuroscience & Biobehavioral Reviews
  • 1993
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Immobilityreducing effect of antidepressants in a genetic animal model of depression

GD Schiller, O Pucilowsky, DH Overstreet
  • Brain Res Bull
  • 1992
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

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