Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression.

@article{Overstreet2004AntidepressantlikeEO,
  title={Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression.},
  author={David H. Overstreet and G. E. Griebel},
  journal={European journal of pharmacology},
  year={2004},
  volume={497 1},
  pages={
          49-53
        }
}
Much interest has been expressed in the antidepressant potential of nonpeptide, orally active corticotropin-releasing factor (CRF) receptor antagonists in recent years. Therefore, the present investigation examined the antidepressant-like effects of the novel CRF(1) receptor antagonist SSR125543 on the exaggerated swim test immobility in the Flinders Sensitive Line rat, a genetic animal model of depression. Chronic treatment with SSR125543 (3, 10, 20, 30 mg/kg, i.p.) for 14 days significantly… CONTINUE READING
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